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Duration of adjuvant trastuzumab in Her2 positive Breast Cancer
Publicado07 Jul 2022
1 Year of Adjuvant Trastuzumab added to chemotherapy has improved DFS & OS compared to no Trastuzumab. 5 non inferiority clinical trials have been conducted to study shorter duration ( 6 months or 9 weeks) of trastuzumab vs 12 months of Trastuzumab to address issue of duration of treatment, concerns with cardiotoxicity & cost of treatment with longer duration. Except PERSEPHONE trial all other clinical trials have not shown benefit compared to 12 months of Trastuzumab. In my practice 1- year of adjuvant Trastuzumab remains standard of care in Her-2 Positive early breast cancer.
