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ESR1 Mutation in clinical practice – A snapshot
Publicados20 Jul 2022
Breast Cancer is heterogenous disease & ER+ve & Her2 Negative (Luminal) is most common subtype of Breast Cancer. For ER+ve & Her2 Negative patients endocrine therapy remains the most important systemic treatment option. Despite offering all the benefits like improved overall survival, response rates & control of symptoms for months or years, patients eventually develop disease progression attributable to complex mechanisms of endocrine resistance. ESR1 mutation is one of the important mechanism of endocrine resistance. ESR1 mutations are found in 15-40% of all patients who progress on 1st line Aromatase Inhibitor therapy. Presence of ESR 1 mutation is prognostic biomarker associated with aggressive disease associated with inferior survival outcomes.
