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Duration of trastuzumab in patients with Her2 positive Metastatic Breast Cancer in prolonged remission
Breast Cancer Published 2 years ago
Improving outcomes in patients with Brain Metastases of Breast Cancer
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Content
Breast Cancer
6m 44s
Duration of adjuvant trastuzumab in Her2 positive Breast Cancer
Published 07 Jul 2022
1 Year of Adjuvant Trastuzumab added to chemotherapy has improved DFS & OS compared to no Trastuzumab. 5 non inferiority clinical trials have been conducted to study shorter duration ( 6 months or 9 weeks) of trastuzumab vs 12 months of Trastuzumab to address issue of duration of treatment, concerns with cardiotoxicity & cost of treatment with longer duration. Except PERSEPHONE trial all other clinical trials have not shown benefit compared to 12 months of Trastuzumab. In my practice 1- year of adjuvant Trastuzumab remains standard of care in Her-2 Positive early breast cancer.
