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Duration of trastuzumab in patients with Her2 positive Metastatic Breast Cancer in prolonged remission
Breast Cancer Published 2 years ago
Improving outcomes in patients with Brain Metastases of Breast Cancer
Breast Cancer Published 2 years ago
Content
Breast Cancer
11m 43s
Sequencing of treatment for Her2 positive MBC in 2022
Published 07 Jul 2022
Noteworthy treatment options added in the treatment guidelines for Her2 positive MBC are Trastuzumab Deruxtecan (TDXd) and combination of Trastuzumab + Capecitabine +Tucatinib. In landmark Destiny Breast 03 study TDXd showed significant PFS benefit compared to TDM1 in Her2 positive MBC patients who have received prior Trastuzumab and Taxane. HER2CLIMB study showed significant PFS & OS benefit for combination of Trastuzumab + Capecitabine +Tucatinib and retained significant activity in patients with brain metastases not requiring immediate treatment.
